Seattle Seahawks Vs. Arizona Cardinals Week 10 NFL Odds, Betting Predictions, Picks and Parlays

Speed Kills: Hawks Go All-In as Kyler Heads to the IR

Well, that's it. The inevitable finally happened in the desert this week, and it’s a total game-changer for the Cardinals, starting this Sunday at Lumen Field. The Arizona Cardinals officially put their franchise QB, Kyler Murray, on injured reserve with that lingering foot injury. It's the right move, honestly. Coach Jonathan Gannon basically admitted that Kyler wasn't "fully healthy" and that forcing him out there was helping no one. He's out for at least four weeks—eligible to return on December 7h against the Rams—so it’s not a season-ender yet, but man, does it feel like drama in Arizona is just piling up right now.

Jacoby Brissett, the seasoned vet, gets the nod, but let’s be real, going into Seattle as a 7-point dog with a backup, no matter how capable, is rough. Brissett’s been solid, he’s a tremendous leader according to guys like Marvin Harrison Jr., but this is the Seahawks. They've got one of the most explosive offenses in the league and now they’re even better.

Why are they better? Because Seattle's front office decided to go full throttle at the trade deadline, dropping some future draft capital—a 2026 fourth and fifth—to snag wide receiver Rashid Shaheed from the Saints. Speed. That's all this trade is about. Shaheed is an absolute burner, a genuine home-run threat who can stretch the field vertically and change the complexity of a defense in one play. 

Adding his deep-ball ability to a room that already features Metcalf, Lockett, and Jaxon Smith-Njigba? That's just unfair. Sam Darnold has been dealing this year, and Shaheed is the kind of weapon that opens up everything underneath for the other guys.

The 45 Over/Under feels about right here, maybe even a little low, considering Seattle's recent scoring binges. The Cardinals’ D needs to step up big time, because they’re going to be on the field a lot. Can Brissett manage the game and get the ball to his targets? Maybe. But they need a lot of stops against a pumped-up Seattle squad making a massive statement with that deadline trade. This looks like a long day for the Cards. Seattle is sniffing that NFC West crown and they just paid for a ticket to ride.