Brooklyn Nets Vs. Boston Celtics Betting Predictions, Picks and Parlays - November 21, 2025

CMC’s Trip Down Memory Lane

The Carolina Panthers and the San Francisco 49ers cap off Week 12 with a Monday Night Football showdown that has "revenge game" written all over it, even if the parties involved are playing nice.

As Christian McCaffrey faces the Panthers for the first time since the blockbuster trade that reshaped the NFC, he admitted to reporters that the week he was shipped off still feels "surreal." But let’s be real—the nostalgia stops at kickoff. At 29, McCaffrey is somehow having his best season yet, leading the Niners in both rushing and receiving. He’s the engine of a 49ers team that just got scary again with the return of Brock Purdy. Purdy, who missed six weeks with that nasty toe injury, looked seamless in his return against Arizona last week (19-of-26, zero turnovers), silencing the "system QB" trolls for at least another news cycle.

For Carolina, Bryce Young has quietly been rewriting his own narrative. He’s strung together three solid outings, finally looking like the franchise savior they promised. But Levi’s Stadium under the lights is a different beast. The Panthers' defense is banged up—star corner Jaycee Horn is questionable with a hip pointer—and asking them to contain a fully healthy Deebo Samuel, George Kittle, and McCaffrey is a tall order. The buzz in the Bay is that Kyle Shanahan has been saving some specific wrinkles for this game to remind Carolina exactly what they gave up.

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The oddsmakers see this getting lopsided, pegging the Niners as 7-point favorites with a Total of 49.5. While Young is playing better, the 49ers' defense at home is a nightmare for young quarterbacks. 

The total feels a bit high given Purdy might still be shaking off rust, but CMC usually hits the over on his own. Prediction: 49ers win comfortably, 27-13, covering the spread while the total stays Under.